AUTHOR=Teng Beina , Duong Michelle , Tossidou Irini , Yu Xuejiao , Schiffer Mario TITLE=Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy JOURNAL=Frontiers in Endocrinology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00179 DOI=10.3389/fendo.2014.00179 ISSN=1664-2392 ABSTRACT=

The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.