AUTHOR=Di Donato Marzia , Giovannelli Pia , Cernera Gustavo , Di Santi Annalisa , Marino Irene , Bilancio Antonio , Galasso Giovanni , Auricchio Ferdinando , Migliaccio Antimo , Castoria Gabriella 

TITLE=Non-Genomic Androgen Action Regulates Proliferative/Migratory Signaling in Stromal Cells

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 5 - 2014

YEAR=2015

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00225

DOI=10.3389/fendo.2014.00225

ISSN=1664-2392

ABSTRACT=Prostate cancer is the major cause of cancer-related death among the male population of Western society, and androgen deprivation therapy represents the first line in prostate cancer treatment. However, although androgen receptor expression is maintained throughout the various stages of prostate cancer, androgen deprivation therapy frequently fails. Clinical studies have demonstrated that different androgen/androgen receptor signalling pathways operate in target tissues. Androgen receptor stimulates growth and transformation of target cells, but under certain conditions slows down their proliferation. 
In this review we discuss the role of androgen receptor in controlling different functions of mesenchymal and transformed mesenchymal cells. Findings here presented support the role of androgen receptor in suppressing proliferation and stimulating migration of stromal cells, with implications for current approaches to cancer therapy.