AUTHOR=Tsutsui Kazuyoshi , Ubuka Takayoshi 

TITLE=GnIH Control of Feeding and Reproductive Behaviors

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 7 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2016.00170

DOI=10.3389/fendo.2016.00170

ISSN=1664-2392

ABSTRACT=In 2000, Tsutsui and colleagues discovered gonadotropin-inhibitory hormone (GnIH) that actively inhibits gonadotropin release and synthesis in birds. Subsequently, extensive studies over the past decade and a half have demonstrated that GnIH is a key neurohormone regulating reproduction across vertebrates, acting on the brain and pituitary to modulate reproduction and reproductive behavior. On the other hand, food deprivation and other metabolic challenges inhibit reproductive axis functioning and sexual motivation. Interestingly, recent studies have further indicated that GnIH controls feeding behavior in vertebrates, such as birds and mammals. This review summarizes the discovery of GnIH and its conservation in vertebrates and the neuroendocrine control of feeding behavior and reproductive behavior by GnIH.