AUTHOR=Webster Nicholas J. G. 

TITLE=Alternative RNA Splicing in the Pathogenesis of Liver Disease

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00133

DOI=10.3389/fendo.2017.00133

ISSN=1664-2392

ABSTRACT=Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic, and currently affects one third of adults or about 1 billion people worldwide. NAFLD is predicted to affect over 50% of the world’s population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a more severe form non-alcoholic steatohepatitis (NASH), as well as insulin resistance, type 2 diabetes mellitus, cirrhosis and eventually hepatocellular carcinoma. This review article will focus on the role of alternative splicing in normal liver physiology and dysregulation in liver disease.