AUTHOR=Felício João Soares , Oliveira Alana Ferreira de , Peixoto Amanda Soares , Souza Ana Carolina Contente Braga de , Abrahão Neto João Felício , de Melo Franciane Trindade Cunha , Carvalho Carolina Tavares , Lemos Manuela Nascimento de , Cavalcante Sávio Diego Nascimento , Resende Fabricio de Souza , Santos Márcia Costa dos , Motta Ana Regina , Janaú Luísa Corrêa , Yamada Elizabeth Sumi , Felício Karem Miléo 

TITLE=Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00199

DOI=10.3389/fendo.2017.00199

ISSN=1664-2392

ABSTRACT=Background: Some studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD. Methods: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system (CGMS), 24-h ABPM and urine albumin-to-creatinine ratio (UACR) before and after VD supplementation. Results: There was a reduction of DKD prevalence at the end of the study (68% vs 32%; p=0.05), with no changes on insulin doses, HbA1c, glycemic variability (GV) and blood pressure (BP) values. A correlation between percentage variation of VD levels (∆VD) and albuminuria at the end of the study was presented (r= -0.5; p <0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p <0.05). Conclusions: Our pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.