AUTHOR=Sanada Fumihiro , Taniyama Yoshiaki , Muratsu Jun , Otsu Rei , Shimizu Hideo , Rakugi Hiromi , Morishita Ryuichi 

TITLE=IGF Binding Protein-5 Induces Cell Senescence

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00053

DOI=10.3389/fendo.2018.00053

ISSN=1664-2392

ABSTRACT=Cellular senescence is the complex process of deterioration that drives the aging of an organism, resulting in the progressive loss of organ function and eventually phenotypic aging. Senescent cells undergo irreversible growth arrest, usually by inducing telomere shortening. Alternatively, senescence may also occur prematurely in response to various stress stimuli, such as oxidative stress, DNA damage or activated oncogenes. Recently, it has been shown that IGF binding protein-5 (IGFBP-5) with the induction of the tumor suppressor p53 is up regulated during cellular senescence. This mechanism mediates IL-6/gp130-induced premature senescence in human fibroblasts, irradiation-induced premature senescence in human endothelial cells, and replicative senescence in human endothelial cells independent of IGF-I and -II. Additionally, a link between IGFBP-5, hyper-coagulation, and inflammation, which occur with age, has been implicated. Thus, IGFBP-5 seems to play decisive roles in controlling cell senescence and cell inflammation. In this review, we describe the accumulating evidence for this role of IGFBP-5 including our new finding.