AUTHOR=Garcia de la Serrana Daniel , Macqueen Daniel J. 

TITLE=Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00080

DOI=10.3389/fendo.2018.00080

ISSN=1664-2392

ABSTRACT=<p>The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation—with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.</p>