AUTHOR=Araki Takako , Liu Ning-Ai 

TITLE=Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00444

DOI=10.3389/fendo.2018.00444

ISSN=1664-2392

ABSTRACT=<p>Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from <italic>in vitro</italic> human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.</p>