AUTHOR=Ren Huan , Tan Sheng-Lan , Liu Mou-Ze , Banh Hoan L. , Luo Jian-Quan 

TITLE=Association of PON2 Gene Polymorphisms (Ser311Cys and Ala148Gly) With the Risk of Developing Type 2 Diabetes Mellitus in the Chinese Population

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00495

DOI=10.3389/fendo.2018.00495

ISSN=1664-2392

ABSTRACT=Abstract  
Background: The association between paraoxonase 2 (PON2) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been extensively investigated in the Chinese population with conflicting results. In this study, we systemically evaluated the association between PON2 Ser311Cys and Ala148Gly polymorphisms and T2DM risk by pooling all relevant studies.
Methods: We searched the PubMed, Embase, CNKI and Wanfang databases for studies. The strength of association was determined in the allelic, homozygous, heterozygous, recessive and dominant genetic models and measured as odds ratio (OR) and 95% confidence interval (CI), under fixed- or random-effect models.
Results: There was no significant association between PON2 Ser311Cys polymorphism and T2DM under all genetic models: allelic (OR = 1.06, 95% CI = 0.77-1.45; P = 0.721), heterozygous (OR = 1.13, 95% CI = 0.87-1.45; P = 0.362), dominant (OR = 1.10, 95% CI = 0.80-1.51; p = 0.562), recessive (OR = 0.87, 95% CI = 0.48-1.58; P = 0.648), homozygous (OR = 0.94, 95% CI = 0.47-1.89; P = 0.865). Similarly, no significant association was found for PON2 Arg148Gly polymorphism in all models: allelic (OR =  1.17, 95% CI = 0.91-1.50; P = 0.218), heterozygous (OR = 1.28, 95% CI = 0.94-1.74; P = 0.117), dominant (OR = 1.25, 95% CI = 0.93-1.67; P = 0.142), recessive (OR = 0.99, 95% CI = 0.52-1.88; P = 0.973), homozygous (OR = 1.08, 95% CI = 0.57-2.07; P = 0.08).
Conclusions: The PON2 Ser311Cys and Ala148Gly polymorphisms were not associated with the risk of T2DM in the Chinese population.