AUTHOR=Liu Xiaoshuang , Tang Chao , Wen Guodao , Zhong Chunyu , Yang Jin , Zhu Junhao , Ma Chiyuan TITLE=The Mechanism and Pathways of Dopamine and Dopamine Agonists in Prolactinomas JOURNAL=Frontiers in Endocrinology VOLUME=Volume 9 - 2018 YEAR=2019 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00768 DOI=10.3389/fendo.2018.00768 ISSN=1664-2392 ABSTRACT=Dopamine agonists (DAs) such as bromocriptine (BRC) and cabergoline(CAB) are the primary treatment choice for prolactinoma by inhibiting prolactin secretion and reducing tumour size. However, the mechanism of dopamine and DAs lead to the death of tumor cells are incompletely understood and some are even conflicting conclusions. The aim of this review is to summarize the different signaling pathways of dopamine and DAs in the treatment of prolactinomas to help better understanding of their functional and drug resistance mechanisms.