AUTHOR=Alfaro Iván E. , Albornoz Amelina , Molina Alfredo , Moreno José , Cordero Karina , Criollo Alfredo , Budini Mauricio 

TITLE=Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00778

DOI=10.3389/fendo.2018.00778

ISSN=1664-2392

ABSTRACT=Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major proteins players of CMA are LAMP-2A and Hsc70. Whereas LAMP-2A works as receptor for protein substrates at the lysosomal membrane, Hsc70 specifically binds protein targets and takes them for CMA degradation. Because of the broad spectrum of proteins able to be degraded by CMA, this pathway has been involved in physiological and pathological processes like lipid and carbohydrate metabolism, and neurodegenerative diseases, respectively. Both, CMA, and the mentioned processes, are affected by aging and by inadequate nutritional habits like high fat diet or high carbohydrate diet. Little is known regarding to CMA being considered as a common regulation factor that links metabolism with neurodegenerative disorders. This review summarizes what is known about CMA, focusing the attention in its molecular mechanism, its role in protein, lipid and carbohydrate metabolism. In addition, the review will discuss how CMA could be a link to connect protein, lipids and carbohydrate metabolism with neurodegenerative diseases. Furthermore, it will be discussed how aging and inadequate nutritional habits, can have an impact at both, CMA activity and neurodegenerative disorders.