AUTHOR=Fénichel Patrick , Chevalier Nicolas , Lahlou Najiba , Coquillard Patrick , Wagner-Mahler Kathy , Pugeat Michel , Panaïa-Ferrari Patricia , Brucker-Davis Françoise 

TITLE=Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00786

DOI=10.3389/fendo.2018.00786

ISSN=1664-2392

ABSTRACT=Cryptorchidism, a frequent genital malformation in male newborn, remains in most cases idiopathic. On the basis of experimental, epidemiological and clinical data, it has been included in the testicular dysgenesis syndrome and believed to be influenced, together with genetic and anatomic factors, by maternal exposure to endocrine disrupting chemicals (EDCs). Here we analyze how EDCs may interfere with the control of testicular descent, which is regulated by two Leydig cell hormones, testosterone and insulin like peptide 3 (INSL3).