AUTHOR=Coon Steven L. , Fu Cong , Hartley Steven W. , Holtzclaw Lynne , Mays Joseph C. , Kelly Michael C. , Kelley Matthew W. , Mullikin James C. , Rath Martin F. , Savastano Luis E. , Klein David C. 

TITLE=Single Cell Sequencing of the Pineal Gland: The Next Chapter

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00590

DOI=10.3389/fendo.2019.00590

ISSN=1664-2392

ABSTRACT=The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of the entire transcriptome and, most recently, the sequencing of the transcriptome of individual cells.  It has been possible to identify at least nine distinct cell types in the pineal gland of the rat, allowing for the first time identification of the precise cells of origin and  expression of transcripts.  Here the  current state of knowledge generated by these transcriptomic efforts is reviewed, with emphasis on the highlights insights suggested by the findings.