AUTHOR=Chen Xuejiao , Hua Wenfeng , Huang Xin , Chen Yuming , Zhang Junguo , Li Guowei 

TITLE=Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 10 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00911

DOI=10.3389/fendo.2019.00911

ISSN=1664-2392

ABSTRACT=Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone development and metabolism. In this review, we summarize the most up-to-date evidence of m6A RNA modification in osteoporosis and highlight the potential role of m6A in prevention, treatment and management of osteoporosis.