AUTHOR=Yuan Mingyang , Li Weidong , Zhu Yan , Yu Boyao , Wu Jing 

TITLE=Asprosin: A Novel Player in Metabolic Diseases

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00064

DOI=10.3389/fendo.2020.00064

ISSN=1664-2392

ABSTRACT=<p>Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene <italic>Fibrillin 1</italic> (<italic>FBN1</italic>) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment.</p>