AUTHOR=Zhang Jinjia , Gao Yiyang , Li Yongze , Teng Di , Xue Yuanming , Yan Li , Yang Jing , Yang Lihui , Yao Yongli , Ba Jianming , Chen Bing , Du Jianling , He Lanjie , Lai Xiaoyang , Teng Xiaochun , Shi Xiaoguang , Li Yanbo , Chi Haiyi , Liao Eryuan , Liu Chao , Liu Libin , Qin Guijun , Qin Yingfen , Quan Huibiao , Shi Bingyin , Sun Hui , Tang Xulei , Tong Nanwei , Wang Guixia , Zhang Jin-an , Wang Youmin , Ye Zhen , Zhang Qiao , Zhang Lihui , Zhu Jun , Zhu Mei , Teng Weiping , Shan Zhongyan , Li Jing 

TITLE=The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00139

DOI=10.3389/fendo.2020.00139

ISSN=1664-2392

ABSTRACT=Purpose: The expression of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid auto-antibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population.
Methods: The data of this study was derived from the Thyroid Disease, Iodine status and Diabetes National epidemiological (TIDE) survey, a recent national survey. A total of 17964 subjects including 5802 males (4000 with TPOAb-TgAb- and 1802 with TPOAb+/TgAb+) and 12162 females (8000 with TPOAb-TgAb- and 4162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb-TgAb- and those with TPOAb+TgAb-, TPOAb-TgAb+, TPOAb+TgAb+, respectively.
Results: Both the fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed a decreased trend in TPOAb-TgAb+ males as compared with those TPOAb-TgAb- men. There were significantly lower FBG and higher HDL-C levels as well as tendencies to decreased incidences of IGT and hypertriglyceridemia in the TPOAb-TgAb+ females when compared with those TPOAb-TgAb- women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.688 (0.501-0.945). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.860 (0.749-0.988). Trend test showed that with the increase of serum TgAb level, there was a tendency of decrease in the prevalence of IFG among the men (P for trend=0.064) and that of hypertriglyceridemia in women (P for trend=0.047) who were all euthyroid.
Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms related to these interesting phenomena await further investigation.