AUTHOR=Liu Zeming , Li Jinpeng , Huang Jianglong , Guo Liang , Gao Rongfen , Luo Kuan , Zeng Guang , Zhang Tingbao , Yi Meilin , Huang Yihui , Chen Jincao , Yang Yibin , Wu Xiaohui 

TITLE=Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00478

DOI=10.3389/fendo.2020.00478

ISSN=1664-2392

ABSTRACT=Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. 
Methods: This study enrolled 1880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. 
Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8% vs. 0%, p=0.001). However, patients with and without diabetes showed no difference in the follow-up period (p=0.993). The mortality rate in patients with or without diabetes was 2.9% (n=4) and 1.1% (n=9), respectively (p=0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p values > 0.05).
Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.