AUTHOR=Sun Qing , Yan Bin , Yang Dan , Guo Jie , Wang Chao , Zhang Qian , Shi Yue , Shi Xiaohu , Tian Guoqing , Liang Xiaochun 

TITLE=Serum Adiponectin Levels Are Positively Associated With Diabetic Peripheral Neuropathy in Chinese Patients With Type 2 Diabetes

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.567959

DOI=10.3389/fendo.2020.567959

ISSN=1664-2392

ABSTRACT=Objective: To investigate the association between serum adiponectin levels and diabetic peripheral neuropathy (DPN) in Chinese type 2 diabetes (T2D) patients.
Design and Methods: A total of 219 T2D patients aged 40-79 years were divided into two groups according to whether they had DPN. The systemic levels of potential five biomarkers were measured by using a human adipokine multiplexed bead-based immunoassay. Diabetic peripheral neuropathy diagnostic criteria included both common DPN symptoms and neurological screening tests. 
Results: Most features of DPN and non-DPN patients are similar, but the DPN patients were slightly older, had longer diabetes duration, higher hemoglobin (Hb) A1c, lower estimated glomerular filtration rate (eGFR) levels, less exercise, and more often used lipid-lowering drugs. Serum adiponectin levels of DPN patients were higher than that of non-DPN patients (8.13 vs. 9.63 mg/ml, P = 0.004). Serum adiponectin levels were positively associated with DPN after adjustment for age, gender, body mass index, hypertension, HbA1c, alcohol intake, smoking status, physical activity, log-transformed low density lipoprotein cholesterol, the use of lipid-lowering drugs, eGFR and diabetes duration [OR 1.72 (95% CI 1.02-2.89), P = 0.041]. 
Conclusions: Serum adiponectin levels of DPN patients were higher compared with non DPN patients in this Chinese T2D population. Higher serum adiponectin levels might be an independent risk factor in the pathogenesis of DPN.