AUTHOR=Song Shiyu , Niu Mengyuan , Liang Qiao , Wang Lei , Min Haiyan , Peng Yuming , Wang Hongwei , Gao Qian 

TITLE=Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.573824

DOI=10.3389/fendo.2021.573824

ISSN=1664-2392

ABSTRACT=Statin treatment is a major prevention for the treatment of hypercholesterolemia and the management of patients with increased risk of cardiovascular disease (CVD) with an evident protective effect. However, its long-term safety was questioned regarding its potential role in new-onset type 2 diabetes mellitus, and its effect on gene regulation in the liver was not fully understood. Herein, by reanalyzing the transcriptome of the livers of obesity and hypercholesterolemia patients, we showed a multiple module organization that related with various clinical metabolic parameters and identified an expression hierarchical network involving cholesterol and fatty acid syntheses in the liver of statin-treated patients. The key genes of the network were validated by QPCR in the hepatocytes upon statin treatment. The upregulation of the key enzymes involving the synthesis of Acetyl-CoA and the induction of a gentle global acetylation of pan-protein and histone H4 in hepatocytes were observed. The study might provide an overall view on statin effect on transcriptional and post-transcriptional regulation of genes in the liver.