AUTHOR=Zhou Qian , Cai Ming , Gou Juxiang , Ning Ning 

TITLE=Effect of Postoperative High-Concentration Oxygen on Recovery After Thyroid Surgery: A Prospective, Open, Randomized, Controlled Study

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.595571

DOI=10.3389/fendo.2021.595571

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>To investigate the effectiveness of high-concentration oxygen on the improvement of throat symptoms and voice changes after thyroid surgery and its protection of the parathyroid function.</p></sec><sec><title>Methods</title><p>A total of 600 patients undergoing thyroid surgery who met the inclusion criteria were randomly divided into the experimental group (n = 300) and the control group (n = 300) by using a random number generator. The patients in the experimental group underwent high-oxygen treatment [FiO<sub>2</sub>80 (8 L/min)] for 6 continuous hours after returning to the ward after surgery. The patients in the control group underwent low-oxygen treatment [FiO<sub>2</sub>30 (2 L/min)] for 6 continuous hours after returning to the ward after surgery.</p></sec><sec><title>Results</title><p>The postoperative incision pain score of patients in the experimental group was significantly better than that in the control group at 6 h (1.07 ± 0.80 <italic>VS</italic> 1.23 ± 0.95, <italic>P</italic>=0.031) and 12 h (1.08 ± 0.64 <italic>VS</italic> 1.20 ± 0.73, <italic>P</italic>=0.041). The postoperative throat pain score of the patients in the experimental group was significantly better than that of the control group at 6 h (1.40 ± 0.85 <italic>VS</italic> 1.59 ± 0.97, <italic>P</italic>=0.011) and 12 h (1.40 ± 0.85 <italic>VS</italic> 1.59 ± 0.97, <italic>P</italic>=0.019). The PONV score of the patients in the experimental group was significantly better than that of the control group at 12 h (0.09 ± 0.19 <italic>VS</italic> 0.14 ± 0.37, <italic>P</italic>=0.024). The Voice Handicap Index score of the patients in the experimental group was significantly better than that of the control group at 24 h (2.89 ± 5.92 <italic>VS</italic> 4.10 ± 6.31, <italic>P</italic>=0.017), 36 h (2.46 ± 5.06 <italic>VS</italic> 3.43 ± 5.97, <italic>P</italic>=0.035), and 48 h (2.46 ± 5.06 <italic>VS</italic> 3.43 ± 5.97, <italic>P</italic>=0.032).</p></sec><sec><title>Conclusion</title><p>High-concentration oxygen can alleviate PONV and pain after thyroid surgery, with less severe voice changes potentially. However, its effects on swallowing function, and parathyroid function need to be further verified.</p></sec><sec><title>Clinical Trial Registration Number</title><p>ChiCTR-IOR-17012765 (China Clinical Trial Registry clinical trial registration center [<uri xlink:href="http://www.chictr.org.cn/index.aspx" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.chictr.org.cn/index.aspx</uri>)</p></sec>