AUTHOR=Adamska Agnieszka , Popławska-Kita Anna , Siewko Katarzyna , Łebkowska Agnieszka , Krentowska Anna , Buczyńska Angelika , Popławski Łukasz , Szumowski Piotr , Szelachowska Małgorzata , Krętowski Adam Jacek , Kowalska Irina 

TITLE=Body Composition and Serum Anti-Müllerian Hormone Levels in Euthyroid Caucasian Women With Hashimoto Thyroiditis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.657752

DOI=10.3389/fendo.2021.657752

ISSN=1664-2392

ABSTRACT=Objective: Women with Hashimoto thyroiditis (HT) are characterized by increased incidence of infertility and disturbances in body composition. Serum anti-Müllerian hormone (AMH), which reflects funcional ovarian reserve, is decreased in women with HT and it be related to body mass. The aim of the present study was to investigate the relation between serum levels of AMH and body composition in HT compared to control group.
Patients and Methods: We examined 85 euthyroid women: 39 subjects with HT and 46 control women. Body composition was analysed by dual-energy X-ray absorptiometry and with bioimpedance method. Serum concentrations of AMH, leptin, TSH, thyroid hormones were assessed.
Results: We observed lower serum concentration of AMH in women with HT in comparison to the control group (p=0.01) estimated with bioimpedance method, but without differences in serum concentration of leptin between studied groups (p=0.28). Women with HT were characterized by higher %body fat (p=0.01) without differences in BMI, android and gynoid fat mass and visceral adipose tissue (VAT) mass with DXA method when compared to the control group (all p>0.05). We found a positive relationship between serum concentration of AMH and %body fat (r=-0.38,p=0.03) in women with HT. Additionally, in HT group, the relationship between serum levels of AMH and leptin was not statistically significant (r=0.01,p=0.96). We observed a relationship between serum concentration of leptin and BMI, %body fat mass, android, gynoid and VAT mass in HT and in the control group (all p<0.01).
Conclusions: Women with HT are characterized by lower levels of AMH and it is associated with higher fat mass, independently of serum levels of leptin.