AUTHOR=Yang Ai-Min , Cui Na , Sun Yi-Fei , Hao Gui-Min 

TITLE=Letrozole for Female Infertility

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.676133

DOI=10.3389/fendo.2021.676133

ISSN=1664-2392

ABSTRACT=Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in a wide range of infertility  settings. It has been more than twenty years since the initial clinical trial of using  letrozole for ovulation induction. In light of the accumulating clinical and basis  research evidence, the efficacy and safety of letrozole have been identifying. This mini review focuses on our current knowledge of the applications and  mechanisms of letrozole for female infertility and various questions put forward about  how letrozole could be more effectively used