AUTHOR=Chen Ziwei , He Jing , Ma Qiang , Xiao Mingbing 

TITLE=Association Between C-Peptide Level and Subclinical Myocardial Injury

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.680501

DOI=10.3389/fendo.2021.680501

ISSN=1664-2392

ABSTRACT=Abstract
Background: Previous studies have confirmed an association between C-peptide levels with the risk of cardiometabolic diseases. However, whether circulating C-peptide was related to subclinical myocardial injury (SC-MI) remained unknown.
Methods: A total of 3752 participants without a history of cardiovascular diseases were included in our study from National Health and Nutrition Examination Survey III (NHANES III). Multivariable linear regression was performed to explore the correlation between C-peptide and cardiac injury score (CIIS). Multivariate logistic regression was used to examine the association of C-peptide quartile and SC-MI. 
Results: Circulating C-peptide was significantly associated with CIIS (β:0.09, 95% confidence interval [CI]: 0.00-0.17; p=0.041). Compared with the lowest quartile, the highest quartile of circulating C-peptide increased a 1.48-fold risk of SC-MI (Odds ratio=1.66, 95% CI: 1.18-1.87; p=0.001). 
Conclusions: The level of C-peptide was independently associated with CIIS and SC-MI, which could serve as a new risk factor of SC-MI.