AUTHOR=Chen Ziwei , He Jing , Ma Qiang , Xiao Mingbing 

TITLE=Association Between C-Peptide Level and Subclinical Myocardial Injury

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.680501

DOI=10.3389/fendo.2021.680501

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Previous studies have confirmed an association between C-peptide levels with the risk of cardiometabolic diseases. However, whether circulating C-peptide was related to subclinical myocardial injury (SC-MI) remains unknown.</p></sec><sec><title>Methods</title><p>A total of 3,752 participants without a history of cardiovascular diseases were included in our study from National Health and Nutrition Examination Survey III (NHANES III). Multivariable linear regression was performed to explore the correlation between C-peptide and cardiac injury score (CIIS). Multivariate logistic regression was used to examine the association between C-peptide quartile and SC-MI.</p></sec><sec><title>Results</title><p>Circulating C-peptide was significantly associated with CIIS (β:0.09, 95% confidence interval [CI]: 0.00–0.17; <italic>p</italic> = 0.041). Compared with the lowest quartile, the highest quartile of circulating C-peptide increased a 1.48-fold risk of SC-MI (Odds ratio = 1.66, 95% CI: 1.18–1.87; <italic>p</italic> = 0.001).</p></sec><sec><title>Conclusions</title><p>The level of C-peptide was independently associated with CIIS and SC-MI, which could serve as a new risk factor of SC-MI.</p></sec>