AUTHOR=Wang Hai-Dan , Zhang Cai-Shun , Li Man-Wen , Lin Qian , Zhang Qing , Liu De-Feng , Ma Zheng-Ye , Dong Jing 

TITLE=The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.708139

DOI=10.3389/fendo.2021.708139

ISSN=1664-2392

ABSTRACT=Background: Insulin resistance (IR) is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) maybe involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.
Methods: The literature search was performed in PubMed, Embase, and Web of Science using the keywords “receptors, Adrenergic, beta-3” and “insulin resistance” from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity, and Egger’s test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.
Results: We included eight papers with 1586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference=0.20, 95% confidence intervals: 0.00 to 0.39, I2=57.6%, p=0.016). However, there was no association between Trp64Arg and the homeostasis model (HOMA-IR) assessment. Egger’s tests showed no publication bias, sensitivity analysis showed that our results were stable. Regression analysis revealed no source of heterogeneity.
Conclusion: Trp64Arg may be associated with IR. European ancestry, obesity, plasm insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.