AUTHOR=Wang Yuxiu , Zhang Jiaoyue , Li Huiqing , Kong Wen , Zheng Juan , Li Yan , Wei Qi , Li Qin , Yang Li , Xu Ying , Li Li , Wang Hanyu , Sun Hui , Xia Wenfang , Liu Geng , Zhong Xueyu , Qiu Kangli , Wang Han , Liu Hua , Song Xiaoli , Xiong Si , Liu Yumei , Cui Zhenhai , Chen Lulu , Zeng Tianshu 

TITLE=Prognostic Value of Leucocyte to High-Density Lipoprotein-Cholesterol Ratios in COVID-19 Patients and the Diabetes Subgroup

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.727419

DOI=10.3389/fendo.2021.727419

ISSN=1664-2392

ABSTRACT=Blood parameters, such as NLR, have been identified as reliable inflammatory markers with diagnostic and predictive value for COVID-19. However, novel hematological parameters derived from HDL-C have rarely been studied as indicators for the risk of poor outcomes in patients with SARS-CoV-2 infection. We aimed to assess the prognostic value of these novel biomarkers in COVID-19 patients and the diabetes subgroup.
We conducted a multicenter retrospective cohort study involving all hospitalized patients with COVID-19 from January to March 2020 in five hospitals in Wuhan, China. Demographics, clinical and laboratory findings, and outcomes were recorded. Neutrophil to HDL-C ratio (NHR), monocyte to HDL-C ratio (MHR), lymphocyte to HDL-C ratio (LHR), and platelet to HDL-C ratio (PHR) were investigated and compared in both the overall population and the subgroup with diabetes. The associations between blood parameters at admission with primary composite end-point events (including mechanical ventilation, admission to the intensive care unit, or death) were analyzed using Cox proportional hazards regression models. Receiver operating characteristic curves were used to compare the utility of different blood parameters.  
 Of 440 patients with COVID-19, 67 (15.2%) were critically ill. On admission, HDL-C concentration was decreased while NHR was high in patients with critical compared with non-critical COVID-19, and were independently associated with poor outcome as continuous variables in the overall population (HR: 0.213, 95% CI 0.090–0.507; HR: 1.066, 95% CI 1.030–1.103, respectively) after adjusting for confounding factors. Additionally, when HDL-C and NHR were examined as categorical variables, the HRs and 95% CIs for tertile 3 vs. tertile 1 were 0.280 (0.128–0.612) and 4.458 (1.817–10.938), respectively. Similar results were observed in the diabetes subgroup. ROC curves showed that the NHR had good performance in predicting worse outcomes. The cutoff point of the NHR was 5.50. However, the data in our present study could not confirm the possible predictive effect of LHR, MHR, and PHR on COVID-19 severity.
 Lower HDL-C concentrations and higher NHR at admission were observed in patients with critical COVID-19 than in those with noncritical COVID-19, and were significantly associated with a poor prognosis in COVID-19 patients as well as in the diabetes subgroup.