AUTHOR=Wang Haoyu , Zhang Yu , Fang Xuhui , Kwak-Kim Joanne , Wu Li 

TITLE=Insulin Resistance Adversely Affect IVF Outcomes in Lean Women Without PCOS

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.734638

DOI=10.3389/fendo.2021.734638

ISSN=1664-2392

ABSTRACT=Objective: To investigate the effects of insulin resistance (IR) on IVF outcomes and a potential underlying mechanism in lean women without PCOS.
Design: A prospective cohort study at the University Clinic.
Setting: IVF center at the University setting. 
Patients:  A total of 155 lean women (body mass index <25) without PCOS undergoing IVF cycle. 
Intervention:  Patients were allocated to IR and non-IR groups based on HOMA-M120.  
Main outcome measure(s):  IVF outcomes, including egg quality, the number of mature oocytes, fertilization rate, blastocyst formation rate, advanced embryo rate, and cumulative live birth rate, were investigated. Auto-immune parameters, peripheral blood immunophenotypes, thyroid hormone, homocysteine, and 25-OH-vitamin D3 (25-OH-VD3) levels were analyzed.
Results: 
The number of mature oocytes and blastocyst formation rate were significantly lower in the IR group as compared with those of the non-IR group (p<0.05, respectively). The proportion of peripheral blood CD19+ B cells was significantly higher in the IR group than those of the non-IR group (p<0.05). Homocysteine, 25-OH-VD3, and auto-immune parameters were the same between the two groups.
Conclusion:
In lean non-PCOS infertile women, IR is associated with the decreased number of mature eggs and poor embryo quality in which B cell immunity may play a role.