AUTHOR=Lu Kai-Ning , Zhang Yu , Da Jia-Yang , Zhou Tian-han , Zhao Ling-Qian , Peng You , Pan Gang , Shi Jing-Jing , Zhou Li , Ni Ye-Qin , Luo Ding-Cun 

TITLE=A Novel Scoring System for Predicting the Metastases of Posterior Right Recurrent Laryngeal Nerve Lymph Node Involvement in Patients With Papillary Thyroid Carcinoma by Preoperative Ultrasound

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.738138

DOI=10.3389/fendo.2021.738138

ISSN=1664-2392

ABSTRACT=Objective: There is still no good method for clinicians to judge whether a patient needs the right recurrent laryngeal nerve (LN-prRLN) resection before surgery. Our goal was to investigate the correlation between papillary thyroid carcinoma (PTC)characteristics on ultrasonography and metastases of lymph nodes posterior to the LN-prRLN. We also wanted to establish a new scoring system to determine whether patients with papillary thyroid carcinoma require LN-prRLN resection before surgery. 
Patients and Methods: 482 patients with right or bilateral PTC who underwent thyroid gland resection from December 2015 to December 2017 were recruited as study subjects. The relationship between the PTC characteristics on ultrasonography and the metastases of LN-prRLN was analyzed by univariate and logistic regression analyses. Based on the risk factors identified in univariate and logistic regression analysis, a nomogram-based LN-prRLN prediction model was established. 
Result: LN-prRLN were removed from all patients, of which 79 had LN-prRLN metastasis, with a metastasis rate of 16.39%. Multivariate logistic regression analysis revealed that LN-prRLN metastasis was closely related to blood supply, larger tumors (>1 cm) and capsular invasion (all p<0.05). A risk prediction model has been established and fully verified. The calibration curve used to evaluate the nomogram shows that the consistency index was 0.73 ± 0.066.
Conclusion: The PTC characteristics on ultrasonography, such as abundant blood supply, larger tumor (>1 cm) and capsular invasion, are positively correlated with LN-prRLN metastasis. Our scoring system can help surgeons to determine which patients should undergo LN-prRLN resection before surgery. We recommend that the patient’s LN-prRLN resection should be performed when the score is above 52.3.