AUTHOR=Deng Jiang , Zhang Yonghong , Bu Limei , Shi Haitao , Tang Hailing , Wang Shenhao , Wang Qian , Dang Shuangsuo , Li Ming , Han Zhiyi , Lu Xiaolan 

TITLE=The Prevalence, Popular Trends, and Associated and Predictive Factors of Non-Obese Fatty Liver Disease

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.744710

DOI=10.3389/fendo.2021.744710

ISSN=1664-2392

ABSTRACT=Background & Aims: There are few studies on non-obese fatty liver disease,the analysis of its prevalence, popular trends, and associated and predictive factors can provide reference for its prevention and treatment. 
Methods: Individuals with complete data of body mass index, sex, age, and abdominal ultrasound in Karamay Central Hospital from 2009 to 2016 were selected to analyze the prevalence and popular trends of non-obese fatty liver disease(body mass index＜24), and associated and predictive factors.
Results: Between 2009 and 2016, a total of 191,555 medical check-ups were included. The prevalence of non-obese fatty liver disease increased from 1.9% to 5.1% among general medical examinants(P＜0.001), increased from 4.6% to 11.7% in non-obese individuals (P＜0.001). Compared with the non-obese control group, the levels of age, body mass index, blood pressure, fasting blood glucose, triglycerides, total cholesterol and uric acid in the non-obese fatty liver group were higher (P＜0. 05). Even among non-obese subjects,elevated body mass index was associated with a 0.63-fold increased risk for non-obese fatty liver disease (P<0.001, odds ratio=1.63, 95% confidence interval 1.54-1.72) for every one-unit increase in body mass index. The most common abnormal indicator of non-obese fatty liver disease was elevated triglyceride (44.2%), which was also the best predictor of non-obese fatty liver disease (area under the curve =0.795) in non-obese physical examinators.
Conclusions: The prevalence of non-obese fatty liver disease was high and increasing rapidly. Triglyceride is the best predictor of non-obese fatty liver in non-obese physical examinators.