AUTHOR=Panigoro Sonar Soni , Sutandyo Noorwati , Witjaksono Fiastuti , Siregar Nurjati Chairani , Ramli Ramadhan , Hariani Ririn , Pangarsa Eko Adhi , Prajoko Yan Wisnu , Puruhita Niken , Hamdani William , Bayu Dimas , Madjid Mardiana , Yulidar Dedy , Fransiska Jane Estherina , Widyawati Retno , Tripriadi Effif Syofra , F. W. Wiwit Ade , Yunda Dewi Krisna , Pranata Raymond 

TITLE=The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.745236

DOI=10.3389/fendo.2021.745236

ISSN=1664-2392

ABSTRACT=Background
This study aims to evaluate the association between TyG index and breast cancer, and assessing the dose-response between TyG index and breast cancer.
Method
This was a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within one year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dL] × fasting glucose [mg/dL])
Results
There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], p<0.001). When compared to TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), p<0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), p<0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), p=0.002 for the risk of breast cancer. The dose-response relationship was non-linear (p<0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], p<0.001), use of contraception (1.73 [1.15, 2.60], p=0.008), alcohol consumption (OR 2.04 [0.96, 4.35], p=0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], p<0.001) were associated with risk of breast cancer. independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], p=0.004), use of contraception (OR 1.59 [1.02, 2.48], p=0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], p<0.001)
Conclusion
TyG index was associated with breast cancer in a non-linear dose-response fashion