AUTHOR=Ma Chun-Ming , Yin Fu-Zai 

TITLE=The Relationship Between Prediabetes and Bone Mass in Adolescents: Analysis of the National Health and Nutrition Examination Survey From 2005 to 2010

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.749998

DOI=10.3389/fendo.2021.749998

ISSN=1664-2392

ABSTRACT=Objective: The purpose of this study was to observe the relationship between impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and bone mineral density (BMD) in different sites in adolescents. Methods: A retrospective study was conducted on United States adolescents age 12-19 years. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2005–2006, 2007-2008, and 2009-2010 cycles. IFG was defined as fasting plasma glucose (FPG) levels that were ≥5.6 mmol/L and <7.0 mmol/L. IGT was defined as 2-h plasma glucose levels that were ≥7.8 mmol/L and <11.1 mmol/L after oral glucose tolerance test (OGTT). Results: After control for age, gender, race, and body mass index (BMI) Z score, adolescents in different categories of IGT had significantly different levels of areal BMD (aBMD) and bone mineral apparent density (BMAD) (IGT main effect: P < 0.05 for all, 2-way ANOVA). There was no main effect between different categories of IFG with regard to aBMD and BMAD (P>0.05). There was not interaction between IFG and IGT with regard to aBMD and BMAD (P>0.05). In multiple regression analysis, the 2-h plasma glucose maintained an independent association with femoral neck aBMD (β=-0.011, 95%CI: -0.017~-0.006, P<0.001, R2=0.012), total femur aBMD (β=-0.015, 95%CI: -0.021~-0.009, P<0.001, R2=0.018), total spine aBMD (β=-0.015, 95%CI: -0.020~-0.010, P<0.001, R2=0.018) and total spine BMAD (β=-0.002, 95%CI: -0.003~0.000, P=0.006, R2=0.003). Conclusion: The present study demonstrates that BMD was decreased in adolescents with IGT. Two-h plasma glucose, not FPG, negatively correlated with BMD. The effect of 2-h plasma glucose was consistent across the sites of bone.