AUTHOR=Wu Ying , Sun Liankun , Zhuang Zhoudao , Hu Xiaoqing , Dong Delu TITLE=Mitochondrial-Derived Peptides in Diabetes and Its Complications JOURNAL=Frontiers in Endocrinology VOLUME=Volume 12 - 2021 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.808120 DOI=10.3389/fendo.2021.808120 ISSN=1664-2392 ABSTRACT=

The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides.