AUTHOR=Al Refaie Antonella , Baldassini Leonardo , De Vita Michela , Gonnelli Stefano , Caffarelli Carla 

TITLE=Vitamin D and adrenal gland: Myth or reality? A systematic review

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1001065

DOI=10.3389/fendo.2022.1001065

ISSN=1664-2392

ABSTRACT=In recent years, vitamin D has become the protagonist in many studies. From cardiology to oncology the spotlight was on this vitamin. While in the past it was considered for its important role in phospho-calcium metabolism and skeletal disorders; today by studying it better, thousands of scenarios and facets have opened up on this vitamin which is actually a hormone in all respects. There are authoritative studies that demonstrate its activity in vitro and in vivo on: carcinogenesis, inflammation, autoimmunity and endocrinopathies. Its role has been studied in type 1 and type 2 diabetes mellitus, in Hashimoto or Graves’ thyroiditis and even in adrenal gland diseases. In fact, there are sev-eral studies that demonstrate the possible correlations between vitamin D and: Addison’s disease, Cushing disease, hyperaldosteronism or adrenocortical tumors. Moreover this fascinating hormone and adrenal gland even seem to be deeply connected by common genetic path-ways. This review aimed to analyze the works that have tried to study the possible influence of vitamin D on adrenal diseases.
In this review we analyze the works that have tried to study the possible influence of vita-min D on adrenal disease.