AUTHOR=Genovesi Simonetta , Tassistro Elena , Giussani Marco , Lieti Giulia , Patti Ilenia , Orlando Antonina , Montemerlo Massimo , Antolini Laura , Parati Gianfranco 

TITLE=Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1006588

DOI=10.3389/fendo.2022.1006588

ISSN=1664-2392

ABSTRACT=It has been argued that metabolically healthy obesity (MHO) does not increase the risk of cardiovascular disease. The aim of this study is to evaluate whether, in a population of obese children/adolescents, the metabolically unhealthy obesity (MUO) phenotype is associated with higher left ventricular mass index (LVMI) and/or higher prevalence of left ventricular hypertrophy (LVH) than the MHO phenotype. We also tested whether the addition of an insulin resistance index (IR) (HOMA-index >90th percentile by sex and age) and the presence of hyperuricemia (serum uric acid >90th percentile by sex and age) to the definition of MUO better identified obese children with early cardiac damage. Left ventricular hypertrophy was defined as the presence of an LVMI greater than or equal to the age- and sex-specific 95th percentile.
The study population included 459 obese children (males 53.2%, mean age 10.6 [standard deviation, SD 2.6]), of whom 268 (58.4%) were MUO. The left ventricular mass index was higher in MUO children than in MHO children (37.8 vs 36.3 g/m2.7, p=0.015), whereas the percentage of MUO children presenting LVH was only slightly higher in MUO children (31.1 vs 40%, p=0.06). Multiple linear regression analyses showed that the variables significantly associated with higher LVMI were male gender (p<0.01), BMI z-score (p<0.001) and WtHr (p<0.001). Multiple logistic regression analyses showed that the presence of LVH was only significantly associated with higher BMI z-score (p<0.05) and WtHr (p<0.05). The MUO phenotype was not a significant predictor of either higher LVMI or higher LVH prevalence. The MUO phenotype had a low predictive ability on the presence of LVH. The area under the ROC curve was 0.57 (sensitivity 0.64, 1-specificity 0.55). The addition of IR and hyperuricemia to the definition of MUO did not change the results observed with the standard definition of MUO obtained at multivariable analysis. 
The MUO phenotype appears to be of little usefulness in identifying the early presence of cardiac damage in a large population of obese children and adolescents. Excess weight and abdominal obesity are confirmed as an important determinant of early organ damage in obese children.