AUTHOR=Zhang Jing , Ning Jing , Hao Xinyu , Han Xiurui , Fu Wei , Gong Yueqing , Meng Qiao , Ding Shigang , Zhang Jing 

TITLE=Glucagon-like peptide-2 protects the gastric mucosa via regulating blood flow and metabolites

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1036559

DOI=10.3389/fendo.2022.1036559

ISSN=1664-2392

ABSTRACT=Refractory peptic ulcers remain a therapeutic challenge. The direct role of glucagon-like peptide-2 (GLP-2), a gastrointestinal hormone, in the gastric mucosa remains unclear. This study was conducted to evaluate the role of GLP-2 in gastric mucosal lesions and its underlying mechanism. Male Sprague–Dawley rats were divided into three groups and pretreated with GLP-2 by intraperitoneal injection for 30 min following intragastric administration of ethanol for 1 h. Pretreatment with GLP-2 significantly reduced ethanol-induced gastric mucosal lesions by improving the gastric mucosal blood flow examined using a laser Doppler flow meter, Guth Scale, hematoxylin-eosin staining, and two-photon microscopy. LC-MS/MS analyses showed that GLP-2 also maintained a steady state of linoleic acid metabolism. Taken together, GLP-2 defends the gastric mucosa against ethanol-induced lesions by improving gastric microcirculation and affecting linoleic acid metabolism.