AUTHOR=Zhang Wei , Jin Jing-Lu , Zhang Hui-Wen , Zhu Ya-Xin , Dong Qian , Sun Jing , Guo Yuan-Lin , Dou Ke-Fei , Xu Rui-Xia , Li Jian-Jun 

TITLE=The value of HDL subfractions in predicting cardiovascular outcomes in untreated, diabetic patients with stable coronary artery disease: An age- and gender-matched case-control study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1041555

DOI=10.3389/fendo.2022.1041555

ISSN=1664-2392

ABSTRACT=Objective: The aim of the present study was to examine the value of high-density lipoprotein (HDL) subfractions for predicting cardiovascular events (CVEs) in untreated patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (SCAD) using an age-and gender matched case-control study. 

Methods: 185 SCAD patients and 185 T2DM and SCAD patients were enrolled and subjected to a clinical follow-up of CVE. HDL subfractions were analyzed using the Quantimetrix Lipoprint System. The relationship between HDL subfractions and CVEs in patients with T2DM and SCAD was evaluated by Kaplan-Meier analysis and Cox proportional hazard models. 

Results: During a median of 37.7-month follow-up, patients with T2DM and SCAD had a higher percentage of CVEs (p=0.039). The combined concentrations of intermediate and small HDL-C (defined as the mixed HDL subfractions) were related to the event incidence in patients with T2DM and SCAD (p=0.004) and still positively associated with increased CVEs even after adjustment in 3 models. Kaplan-Meier curve analysis displayed those patients with T2DM and SCAD in higher levels of mixed HDL subfractions group (>28mg/dl) had lower event-free survival rates (p=0.008).

Conclusions: Elevated intermediate and small HDL subfractions concentration could predict events in patients with T2DM and SCAD.