AUTHOR=Ling Qin , Chen Jiawei , Liu Xiao , Xu Yi , Ma Jianyong , Yu Peng , Zheng Kai , Liu Fuwei , Luo Jun 

TITLE=The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1043169

DOI=10.3389/fendo.2022.1043169

ISSN=1664-2392

ABSTRACT=Background: The triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose‒response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose‒response association between the TyG index and the risk of NAFLD.
Methods: We systematically searched the Cochrane Library, PubMed, and Embase databases until July 2022 for relevant studies. The robust error meta-regression method was used to investigate the dose‒response association between the TyG index and NAFLD. Summary relative risks (ORs) and 95% CIs were estimated by using a random-effects model.
Results: A total of 4 cohort and 8 cross-sectional studies were included, with 28,788 NAFLD cases among the 105,365 participants. A positive association for the risk of NAFLD was observed for each additional unit of the TyG index with a linear association (p=0.82), and the summary OR was 2.84 (95% CI, 2.01-4.01). In the subgroup analyses, a stronger association of the TyG index with NAFLD was shown in females than in males (men: OR=2.97, 95% CI 2.55-3.46, women: OR=4.80, 95% CI 3.90-5.90, Psubgroup<0.001).
Conclusion: The TyG index may be a novel independent risk factor for NAFLD beyond traditional risk factors.