AUTHOR=Wu Bo , Fu Zhaoyu , Wang Xinyu , Zhou Pengcheng , Yang Qifan , Jiang Ye , Zhu Dong 

TITLE=A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1052592

DOI=10.3389/fendo.2022.1052592

ISSN=1664-2392

ABSTRACT=Recently, the increasing prevalence of diabetes has made it a major chronic illness which poses a substantial threat to human health. The frequency of osteoporosis among patients with diabetes has grown considerably. Diabetic osteoporosis is a secondary osteoporosis induced by diabetes. Patients with diabetic osteoporosis exhibit variable degrees of bone loss, low bone mineral density, bone microarchitecture degradation, and increased bone fragility with continued diabetes, increasing their risk of fracture and impairing their ability to heal after fractures. At present, there is extensive research interest in diabetic osteoporosis and many significant outcomes have been reported. However, a systematic and comprehensive review is still lacking. This review elaborates on diabetic osteoporosis in the aspects of characteristics, pathogenesis, and treatment. A novel bioinformatics analysis was also performed, and ten hub genes of diabetic osteoporosis were screened, wherein the PI3K-Akt signaling pathway was identified as a promising treatment target.