AUTHOR=Alam Safaet , Sarker Md. Moklesur Rahman , Sultana Taposhi Nahid , Chowdhury Md. Nafees Rahman , Rashid Mohammad A. , Chaity Nusrat Islam , Zhao Chao , Xiao Jianbo , Hafez Elsayed E. , Khan Shah Alam , Mohamed Isa Naina TITLE=Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development JOURNAL=Frontiers in Endocrinology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.800714 DOI=10.3389/fendo.2022.800714 ISSN=1664-2392 ABSTRACT=

Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics.