AUTHOR=Tang Xiao-Fang , He Chen , Zhu Pei , Zhang Che , Song Ying , Xu Jing-Jing , Yao Yi , Xu Na , Jiang Ping , Jiang Lin , Gao Zhan , Zhao Xue-yan , Gao Li-jian , Song Lei , Yang Yue-Jin , Gao Run-Lin , Xu Bo , Yuan Jin-Qing 

TITLE=Hyperuricemia is Associated With 2- and 5-Year Adverse Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.852247

DOI=10.3389/fendo.2022.852247

ISSN=1664-2392

ABSTRACT=Background
Despite hyperuricemia has been identified as independent risk factor for cardiovascular diseases, its prognostic value in the setting of ST-segment elevation myocardial infarction (STEMI) is still controversial. Although the mechanisms of this possible relationship are unsettled, it has been suggested that hyperuricemia could trigger the inflammatory response. This study sought to investigate the association between hyperuricemia with long-term mortality and with inflammatory response in patients with STEMI treated with percutaneous coronary intervention (PCI).
Methods
Blood samples were collected on admission of patients with STEMI: the inflammatory biomarkers high sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count were considered. Cumulative 2-years and 5-years mortalities were estimated using the Kaplan-Meier analysis. Multivariable analyses were performed by Cox proportional hazard models.
Results
In the 1448 patients with STEMI considered, 2-years mortality was 5.5% among patients with hyperuricemia and 1.4% among patient with normouricemia (P <0.001); 5-years mortality was 8.0% vs 3.9%, respectively (p =0.004). At multivariable analyses hyperuricemia was an independent predictor of 2-years mortality (hazard ratio (HR) =3.444, 95% confidence interval (CI): 1.621-7.319, P =0.001) and 5-years mortality (HR =1.896, 95% CI: 1.097-3.278, P =0.022). While, there were no difference of hs-CRP, ESR and WBC count on admission in patients with hyperuricemia compared to normouricemia (P >0.05).
Conclusions 
Hyperuricemia was associated with higher 2-years and 5-years mortality in patients with STEMI undergoing PCI. While, our study was not found that hyperuricemia was associated with greater inflammatory response on admission in those patients.