AUTHOR=Oziel-Taieb Sandrine , Maniry-Quellier Jemima , Chanez Brice , Poizat Flora , Ewald Jacques , Niccoli Patricia 

TITLE=Pasireotide for Refractory Hypoglycemia in Malignant Insulinoma- Case Report and Review of the Literature

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.860614

DOI=10.3389/fendo.2022.860614

ISSN=1664-2392

ABSTRACT=Malignant insulinomas are functional neuroendocrine tumors of the pancreas and the primary cause of tumor-related hypoglycemia. Malignant insulinoma is rare and has a poor prognosis. We report a case of malignant insulinoma with metastases in the liver and lymph nodes in a 64-year-old patient with severe and refractory hypoglycemia. After several ineffective locoregional and systemic lines of treatment for the secretory disease, the introduction of pasireotide –a second-generation somatostatin analog— provided an improved clinical and secretory evolution both quickly and sustainably, with an excellent safety profile and antitumor efficacy. Pasireotide is an effective and well-tolerated therapy in the treatment of refractory hypoglycemia in metastatic insulinoma.