AUTHOR=Ruan Yongsheng , Chen Libai , Xie Danfeng , Luo Tingting , Xu Yiqi , Ye Tao , Chen Xiaona , Feng Xiaoqin , Wu Xuedong 

TITLE=Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.865436

DOI=10.3389/fendo.2022.865436

ISSN=1664-2392

ABSTRACT=Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.