AUTHOR=Lee Hye Jin , Lim Youn-Hee , Hong Yun-Chul , Shin Choong Ho , Lee Young Ah 

TITLE=Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.872591

DOI=10.3389/fendo.2022.872591

ISSN=1664-2392

ABSTRACT=Objectives: To investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood. 
Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of IR (HOMA-IR) was calculated as insulin (μIU/mL) × glucose (mg/dL)/405. BMI Z-score quartiles [BMI (Z)] for each age group were defined as Q4, ≥ 75th percentile; Q2-3, 25th to 75th percentile; and Q1, < 25th percentile. Glucose, insulin, and HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4. 
Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dL), insulin (3.2 vs. 2.5 and 2.3 μIU/mL) and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years. 
Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.