AUTHOR=Zhao Yinjiao , Song Peiyu , Zhu Chan , Zhang Lingyun , Chen Xiaoyu , Zhang Hui , Han Peipei , Ding Wei , Niu Jianying , Zhao Junli , Shao Xiang , Zhang Liming , Yu Chen , Xu Jia , Fang Chenghu , Guo Qi 

TITLE=Relationship between physical performance and mild cognitive impairment in elderly hemodialysis patients is modified by the presence of diabetes: A multicenter cross-sectional study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.897728

DOI=10.3389/fendo.2022.897728

ISSN=1664-2392

ABSTRACT=31	Objective: The purpose of this study was to observe the relationship between physical performance
32	and mild cognitive impairment (MCI) in the presence or absence of  type 2 diabetes in elderly
33	hemodialysis patients.
34	Methods: In this multicenter cross-sectional study, 396 clinically stable and aged ≥60 years old
35	hemodialysis patients (male 255; mean age: 68.3±5.9 years) were included from 7 dialysis units in
36	Shanghai, China. The Chinese version of the Modified Mini-Mental State Examination (MMSE) and
37	the Instrumental Activities of Daily Living (IADL) scale were utilized to assess MCI. The
38	performance-based assessments consisted of three physical tests: grip strength (GS), Timed Up and Go
39	test (TUGT) and 4-meter walking test, which respectively represent muscle strength, mobility and
40	walking speed (WS). Logistic and multivariate linear regression were used to analysis.
41	Results: Hemodialysis patients with diabetes had high prevalence of MCI (20.6%). In diabetes patients,
42	TUGT and WS were associated with MCI, and WS was negatively correlated with MCI after adjusting
43	covariates [odds ratio (OR)=0.126; 95% confidence interval (CI)=0.023–0.699, P=0.018]. However,
44	no significant association between GS and MCI either in the non-diabetes or diabetes (P>0.05). Further
45	analysis showed that mobility was associated with attention and calculation, and language. Walking
46	speed was related to recall and language in diabetic hemodialysis patients.
47	Conclusions: Physical performance was associated with MCI in diabetic hemodialysis patients rather
48	than the non-diabetes group. Whether increasing mobility or walking speed can positively influence
49	MCI in individuals with type 2 diabetes requires further study.