AUTHOR=Wang Pengbo , Guo Xiaofan , Zhou Ying , Li Zhao , Yu Shasha , Sun Yingxian , Hua Yu 

TITLE=Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.944991

DOI=10.3389/fendo.2022.944991

ISSN=1664-2392

ABSTRACT=Background: The present study tried to clarify the effects of four inflammatory indicators, monocyte-to-high-density lipoprotein ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), systematic immune-inflammation index (SII) and systemic inflammation response index (SIRI) in evaluating the risk of metabolic diseases and cardiovascular disease (CVD), filling the gap of inflammation-metabolism system in the epidemiology.
Methods: We conducted a cross sectional study and performed multivariable logistic regression to elucidate the association of inflammatory indicators and metabolic diseases and CVD risk. Metabolic diseases were defined as metabolic disorders (MetD) or its components such as metabolic syndrome (MetS), dyslipidemia and central obesity. 10-year CVD risk was calculated by the Framingham risk score (FRS). 
Results: Odds ratios for the third vs the first tertile of MHR were 2.727(95%CI, 2.260-3.289) for MetD, 1.939(95%CI, 1.637-2.298) for MetS, 1.648(95%CI, 1.424-1.908) for dyslipidemia and 1.592(95%CI, 1.387-1.827) for central obesity. Odds ratios for the third vs the first tertile of SIRI were 2.171(95%CI, 1.840-2.560) for MetD, 2.018(95%CI, 1.837,2.217) for MetS, 1.368(95%CI, 1.206,1.551) for dyslipidemia and 1.737(95%CI, 1.459,2.068) for central obesity. The odds ratio of a 10-year CVD risk over 30% for the third vs the first tertile of MHR was 1.437 (95% CI, 1.251-1.651) and 1.393 (95% CI, 1.292-1.502) for SIRI.
Conclusions: MHR and SIRI had significant association with MetD and its components, which a higher level of MHR or SIRI tended to accompany with a higher risk of metabolic diseases. Besides, they also correlated to the CVD which the increment of these indicators brought a gradually evaluated risk of 10-year CVD.