AUTHOR=Ma Fengyu , Luo Shangdie , Lu Chunting , Jiang Xinrong , Chen Kexiao , Deng Jianwen , Ma Shuyuan , Li Zejian 

TITLE=The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.963451

DOI=10.3389/fendo.2022.963451

ISSN=1664-2392

ABSTRACT=Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. Through Kelch-like epichlorohydrin-related protein -1(Keap1)- nuclear factor E2-related factor 2(Nrf2)- antioxidant response element (ARE) signal pathway, it initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes, and plays the role of anti-apoptosis, anti-oxidative stress and reducing inflammation. Studies have shown that Nrf2 plays a major role in the regulation of periodontal disease. This review mainly summarizes the role of Nrf2 in periodontal disease by regulating lipid peroxidation, bone homeostasis, inflammation and apoptosis.