AUTHOR=Bassi Marta , Strati Marina Francesca , Andreottola Valentina , Calevo Maria Grazia , d’Annunzio Giuseppe , Maghnie Mohamad , Minuto Nicola 

TITLE=To sleep or not to sleep: An Italian Control-IQ-uestion

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.996453

DOI=10.3389/fendo.2022.996453

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>Tandem Control-IQ is an advanced hybrid closed loop (AHCL) system with a Sleep Activity Mode to intensify glycemic control overnight. The aim of the study is to evaluate the effectiveness of using Sleep Mode or not among Tandem Control-IQ users.</p></sec><sec><title>Research design and methods</title><p>We performed a retrospective Tandem Control-IQ data download for patients followed at IRCCS G. Gaslini Pediatric Diabetes Centre. We divided the patients into group 1 (Sleep Mode users) and group 2 (non-users) and compared their overall glycemic data, particularly during nighttime.</p></sec><sec><title>Results</title><p>Group 1 (<italic>n</italic> = 49) does not show better nocturnal glycemic control as expected when compared with group 2 (<italic>n</italic> = 34). Group 2 shows a nighttime TIR% of 69.50 versus 66.25 (<italic>p</italic> = 0.20). Only the patients who do not use Sleep Mode and with sensor and automatic mode use ≥90% reached TIR &gt;70% during nighttime, as well as lower nocturnal TAR% (18.80 versus 21.78, <italic>p</italic> = 0.05).</p></sec><sec><title>Conclusions</title><p>This is the first study that evaluates the real-life effectiveness of the use of Sleep Mode in young patients with T1D. Control-IQ Sleep Activity Mode may not be as effective in Italian patients as in American patients due to the different habits.</p></sec>