AUTHOR=Liu Yalong , He Zining , Huang Ning , Zeng Lin , Wang Yang , Li Rong , Chi Hongbin 

TITLE=Impact of thyroid autoimmunity and vitamin D on in vitro fertilization/intracytoplasmic sperm injection outcomes among women with normal thyroid function

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1098975

DOI=10.3389/fendo.2023.1098975

ISSN=1664-2392

ABSTRACT=This prospective cohort study aimed to determine the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilisation/intracytoplasmic sperm injection. The study included 1,297 women who underwent in vitro fertilisation/intracytoplasmic sperm injection cycles. The study endpoints were clinical pregnancy, ongoing pregnancy, ectopic pregnancy, and early miscarriage rates. Our study found that the total 25-hydroxyvitamin D serum concentrations (P<0.001) and anti-Mullerian hormone levels (P=0.019) among patients in the TAI group were lower than those in the non-TAI group. Additionally, the study population in each group was divided into three subgroups according to the total vitamin D status based on clinical practice guidelines (deficient, <20 ng/mL; insufficient, 21–29 ng/mL; and sufficient, ≥30 ng/mL). In the TAI group, the number of good-quality embryos decreased in patients with vitamin D deficiency (P=0.007). Logistic regression analysis indicated that ageing prevented women from achieving clinical (P=0.024) and ongoing pregnancy (P=0.026). The current findings suggest that patients with TAI had reduced serum vitamin D concentration. Furthermore, in the TAI group, the number of good-quality embryos decreased in patients with vitamin D deficiency. Finally, ageing adversely impacted achieving clinical and ongoing pregnancy.