AUTHOR=Liu Shuang , Li Mengdan , Pang Hua , Zuo Rui , Kong Lingquan , Wang Zhengjie , Li Wenbo , Xia Zhu , Wang Dong , Xu Lu 

TITLE=Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism

JOURNAL=Frontiers in Endocrinology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1100056

DOI=10.3389/fendo.2023.1100056

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>We evaluated the difference in parathyroid visualization on <sup>18</sup>F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT.</p></sec><sec><title>Methods</title><p>This retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent <sup>18</sup>F-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses.</p></sec><sec><title>Results</title><p>Dual-time <sup>18</sup>F-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783).</p></sec><sec><title>Conclusion</title><p>The quantitative parameters of 60min <sup>18</sup>F-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT.</p></sec>