AUTHOR=Yan Enqi , Li Wenxuan , Jin Huizi , Zhao Mengya , Chen Dan , Hu Xinyao , Chu Yifan , Guo Yaxin , Jin Lei 

TITLE=Cumulative live birth rates and birth outcomes after IVF/ICSI treatment cycles in young POSEIDON patients: A real-world study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1107406

DOI=10.3389/fendo.2023.1107406

ISSN=1664-2392

ABSTRACT=Objective: The aim of this study is to describe the cumulative live birth rates (CLBRs) of young women with or without low prognosis according to the POSEIDON criteria after IVF/ICSI cycles and to investigate whether diagnosis of low prognosis increase the risk of abnormal birth outcomes.
Design: Retrospective study.
Setting: A single reproductive medicine center.
Population: From January 2016 to October 2020, there were 17,893 patients (<35 years) involved. After screening, 4,105 women were included in POSEIDON group 1, 1,375 women were included in POSEIDON group 3, and 11,876 women were defined as non-POSEIDON.
Intervention(s): Baseline serum AMH level was measured on the D2-D3 of menstrual cycle before IVF/ICSI treatment.
Main Outcome Measure(s): cumulative live birth rate (CLBR), birth outcomes
Result(s): After 4 stimulation cycles, the CLBRs in POSEIDON groups 1, POSEIDON group 3 and non-POSEIDON group reached 67.9% (95%CI 66.5%-69.3%), 51.9% (95%CI 49.2%-54.5%) and 79.6% (95%CI 78.9%-80.3%), respectively. There was no difference in gestational age, preterm delivery, cesarean delivery and low birth weight infants between the three groups, but macrosomia was significantly higher in non-POSEIDON group, after adjusting for maternal age and BMI.
Conclusion(s): POSEIDON group shows lower CLBRs than non-POSEIDON group in young women, while the risk of abnormal birth outcomes in POSEIDON group will not increase.
Keyword(s): low prognosis, POSEIDON criteria, IVF/ICSI, cumulative live birth rates, birth outcomes