AUTHOR=Chen Zhuoyuan , Yang Huiqin , Ren Yunfeng , Yang Ze , Huang Jiazheng , Li Cheng , Xiong Ying , Yu Bin 

TITLE=Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1119534

DOI=10.3389/fendo.2023.1119534

ISSN=1664-2392

ABSTRACT=Adiponectin Receptor 1 (ADIPOR1) and Adiponectin Receptor 2 (ADIPOR2) 
encoded by ADIPOR1 and ADIPOR2 genes respectively, are the receptors of 
adiponectin secreted by adipose tissue. Increased studies have identified the vital role 
of adipose tissue in various diseases, including cancers. Hence, there is an urgent need 
to explore the roles of AdipoR1 and AdipoR2 in cancers. Here, we conducted a 
comprehensive pan-cancer analysis for the roles of AdipoR1 and AdipoR2 via several 
public databases. Both ADIPOR1 and ADIPOR2 were dysregulated in most cancers, 
but their genomic alteration frequencies were low. In addition, they were also correlated 
with the prognosis of some cancers. In addition, ADIPOR1/2 displayed significant 
associations with cancer stemness, tumor immune microenvironment, immune
checkpoint genes (especially CD274 and NRP1), and drug sensitivity. In summary, our 
study revealed that ADIPOR1 and ADIPOR2 played critical roles in diverse cancers, 
and it is a potential strategy to treat tumors through targeting ADIPOR1 and ADIPOR2.